Loneliness is one of those subjects photographers like.
So when you see a lonely flower sticking its head out of a fence, isolate it by focusing carefully and using a narrow depth of field (selective focus is a great way to isolate a subject); then surround it with “negative space” if you like, and shoot:
We like pictures to say something. A sense of isolation is something we can all identify with – we are all, after all, alone, for better or for worse.
A second advantage of this technique is that it simplifies your pictures, and simplicity is so often the hallmark of a great image, that aiming for a simple picture is a good thing.