When shooting Macro pics, you often fight to get enough depth of field. Even f/16 might only get you this:

So why not forget that and play? Selective DOF can be very effective, as in here:

That was f/2.8 with the 100mm macro lens. Doesn’t that make Her Majesty’s eyes stand out nicely?

As in all these things, it is a matter of choosing the technique to suit the message.